Trying to lose weight in our modern society

When writing my last post I came across two interesting studies that I thought were worth mentioning. It is commonly accepted that high carbohydrate diets cause insulin resistance, and this insulin resistance is in order to prevent the damage of high glucose concentrations in the blood stream. However, I personally have not encountered articles that suggest the opposite – low carb diets induce insulin resistance. That was until a few days ago…

A paper by Miller and Cologiuri in Diabetologia found that when implementing a low carbohydrate diet muscles become insulin resistant, and proposed that this is a consequence of our high carbohydrate evolutionary past. Our primate ancestors ate a high-carbohydrate diet, and the brain and reproductive tissues developed a requirement for glucose as fuel. The Ice Ages for the last two million years brought into human evolution a low carbohydrate diet. Thus, certain metabolic adaptations were necessary to accommodate low glucose intake. These authors hypothesised that insulin resistance is a mechanism for coping with a shortage in dietary glucose. Because some of our bodies processes still required glucose, natural selection would have positively selected for those individuals that preserved it through insulin resistance. Interestingly, Europeans have the lowest incidence of diabetes, and this is thought to be because they were the first to adopt agriculture in the last 10,000 years. Thus the selection pressure for insulin resistance was relaxed in this population much earlier.

This carnivore-connection theory is also observed in mammalian carnivores! In a strict carnivore, the house cat, a low carbohydrate diet evokes insulin-resistance while adding in some carbohydrates improves insulin sensitivity. This is astounding since common sense would dictate that carnivores, of all species, would not require glucose and heavily rely on fat and protein, and this remains to be true. However, true carnivores still have specific requirements for glucose in the brain, fetus and mammary glands. Carnivores are evolutionarily adapted to be insulin resistant in the liver and peripheral tissues, and are far more resistant to insulin’s effects than omnivores. The ability of insulin to inhibit glucose production and to promote glucose disposal is detrimental in a system that acquires very little of it. Thus gluconeogenesis is permanently ‘switched on’ in true carnivores and some is also acquired from the organs, and muscle tissue (glycogen) in the animals that they eat. This indicates that insulin sensitivity might be a U-shaped curve, where excessively high or low amounts promote insulin resistance.

In my last post I discussed how, I believe, exercise and micronutrient intake was vital to my successful weight loss. Today, I want to begin a series of posts to talk about the micronutrient side of the equation, and my long-term intention is to explain why you should focus on these rather than macronutrients, and how to do it. Please be aware that this is still only a hypothesis that seems to make sense to me. So I want to explore this idea, and see if it holds water. However, I believe that focusing on micronutrient intake is an often under-looked, briefly mentioned, yet colossally important requirement for any weight loss programme. I make this bold statement based off one simple observation – I never feel hungry when I meet my micronutrient intake for the day, and I feel more energized and motivated. This may sound like a ridiculous way to start a theory, but I know of someone else who made a simple observation when an apple fell out of a tree, and so big ideas have to start from somewhere.

Today I want to question the importance of macronutrients, and perhaps ask why we shouldn’t be putting our focus on micronutrients instead. Micronutrients often get completely overlooked in weight loss discussions, getting no more than a brief mention on how important it is that you should take them, before moving on to whether it should be carbohydrates or fat that we should be eliminating from our diet. They really are the smaller brother to macronutrients…the David to our Goliath. Yet, many micronutrients are not able to be produced in our body, and are essential for survival and well-being, and is this the case for macronutrients? Carbohydrates, for example, are deemed quintessential to life, and yet the body can reduce its dependence on them by burning ketone bodies – a fat.  The body is so efficient at this it can drop the amount of glucose needed by the brain from 120g a day to 30g a day simply by using its ketone bodies as fuel. However, of that 30g of glucose, 20g can be produced in the liver from glycerol, which is itself a product of fat breakdown. Thus, there is very little argument to be made that our body needs a lot of carbohydrates to survive. This is further confirmed by the poster child of low carbers, the Inuit, who obtained 20% of calories from carbohydrate, mostly from the glycogen in the muscle of their kill, and 50% of energy from fat.

Many low carb proponents argue that this evidence is the nail in the coffin for carbohydrates and that a high-fat diet is the way to go. Yet healthy cultures in the past have existed successfully on low fat/high carb diets. The North American Pima, for example, obtained 70-80% of calorie intake from carbohydrates with a measly 10-12% from fat. It was only when they left this diet, and introduced a lower carbohydrate westernised diet that diabetes became rampant in their population. Another example, are the Kitavans from Papua New Guinea whom obtain 70% of their calorie intake from carbohydrates, and 20% from fat. Furthermore, the longest lived people in the world today from the Island of Okinawa (near Japan) obtain 85% of their energy intake from carbohydrates, and 6% from fat. Clearly, macronutrient intake is not the determining factor of living a long and healthy life. All these groups consumed a much higher proportion of carbohydrates than we do by today’s standards, and yet showed little incidence of the diseases we face in our modern society. Thus, a high fat/low carb diet, and a high carb/low fat diet can both produce healthy individuals.

So what is the similarity between these groups? The answer again lies with the people of Okinawa who ate 300% more green/yellow vegetables than their Japanese counterparts, and less rice. This indicates that a large proportion of their diet was a variety of vegetables, which would be loaded with micronutrients and free of processed chemicals. People eating a western diet, plagued with all its modern diseases, consume a large range of macronutrients right across the spectrum, and yet, one of the key differences is that 75% of these people take in less than the recommended daily allowance for vitamins and minerals. This would not be the case for any of the groups mentioned above.  In my opinion, beyond the absolutely basic requirements, it seems that macronutrients could simply be considered as a vehicle to deliver the optimal amount of micronutrients to our bodies, and our bodies are highly adaptable and capable of making the necessary changes in macronutrient intake to do so. Our body can easily interchange between macronutrients, but it certainly cannot do this for vitamins and minerals, which are essential for life and non-negotiable. In fact, the very definition of a vitamin is a vital nutrient that cannot be synthesized in sufficient quantities by the organism and must be obtained from the diet. I believe, that the capability of humans, as omnivores, to adjust the macronutrient portion of our diet in order to maximise the intake of micronutrients is a key factor in our evolutionary success.

But what about the ecology of a westerner living in today’s society? How do we adjust our macronutrient intake to ensure our micronutrients are over the RDA? I will answer these questions in upcoming posts within this series along with the vital importance of minerals and vitamins in our diet, how the optimal dosage of these cannot be interchanged or swapped around like macronutrients, and I will highlight that obtaining micronutrients from food, and not from supplements, is far more important than concerning oneself with macronutrient intake. Please let me know what you think. I am no expert in this area and the more people that comment, and make suggestions, the more informative this blog will become.

I want to finish off this post with some questions. (1) name a healthy human population that does not also obtain a sufficient supply of micronutrients from their food supply? (2) name a healthy human population that does not eat a high carb or  (3) high fat diet? It is much easier to come up with an example for the later questions, than it is for the former. I think this emphasises how we need to start paying more attention to our micronutrient intake, and aim for optimal nutrition.

In the past I have attempted to lose weight and never succeeded long-term. I had some luck on the paleo diet, but the weight came back. When it was strictly paleo I kept having episodes where I fell off the wagon and ate ‘bad’ foods, and then found it harder to get back on the wagon again, and continue with the weight loss. In contrast, I also tried a more relaxed primal type of eating where I allowed myself dairy, salt and fat. The fat part was because originally when I was following a stricter paleo regime saturated fats were still considered to be best avoided. On the more primal version adherence was no problem, but the weight certainly didn’t shift either. The conundrum was that as a biological scientist an evolutionary approach to eating made the most sense to me, but this approach didn’t seem to work. So there was never a question in my mind that this was the diet for me, but the implementation kept failing me.

A month ago I decided to do it again. My friend had been pestering me to go to the gym with him as I had put on all my old weight and more! One of those friends that never mentions you are getting fatter, but the implication is pretty much assumed. Begrudgingly, I went and started to walk on a treadmill for an hour. I haven’t exercised for over 10 years, and I had forgotten just how amazing it can make you feel. Previously, I had never wanted to exercise or, at least, felt it unworthy of my time since study after study has shown it does nothing for weight loss. The paradox here is that people who do exercise swear by it. I had assumed that exercise was only good in that it stopped you from losing muscle, and so your body burned more fat, and this is why I agreed to do it in the first place. But what I had forgotten was the feeling that exercise gives you. My mood felt lighter, and more energized. I felt more powerful, and I liked how it felt when my body moved. After some time I could move without groaning or feeling exhausted. Exercise completely rejuvenated me, and gave me a sense of purpose, and the energy and motivation to pursue it.

Through the exercise I felt the want, not the need, to stick to a paleo diet. I wasn’t eating good food to lose weight, although I was, I was eating these foods because my body demanded it. In order to obtain future weight loss success I came up with an eating plan based on my past weight loss failures. One question was whether or not to count calories? Philosophically, I despised having to count calories; it made me feel like a slave to the diet. On the other hand logic told me that if I did not count calories, as I had not when eating a more primal diet, the weight would simply maintain itself. Unfortunately, an evolutionary diet is not a miracle cure, and I felt some pain would be necessary to get that weight moving.  So I aimed to eat 2000 calories per day, and I also decided to keep my carbohydrates below 50g since the evidence suggests this can prevent hunger. But then the most pleasant, yet unexpected, thing happened. Each day, when I counted the calories and carbs, I noticed a lot of my vitamins and/or minerals were not reaching the recommended daily allowance.  Being the pedantic scientist that I am I became determined to get the maximum amount of nutrients for the minimal amount of calories, and so over time I started adding certain foods, subtracting other foods, and eventually I got it right. What I didn’t realise was how amazing I would feel once I did develop my diet to a place where I was receiving maximal nutrient intake (see nutrient breakdown for today below). Having a massive amount of vitamins and minerals coursing through my veins brought on my second wave of ‘oh my god I feel so good I can’t believe it’. Once again I felt energized, but also calm and relaxed. All this and the hunger I was so petrified of facing didn’t even rear its ugly head, in fact, I felt abundantly content with the mere 2000 calories I was eating a day.

Vitamin A 4200.5 mcg 900 467% Magnesium 582.91 mg 420 139%
Vitamin A 57715.9 IU Manganese 4.69 mg 2.3 204%
Vitamin B6 4.44 mg 1.3 342% Niacin 35.71 mg 16 223%
Vitamin B12 9.8 mcg 2.4 407% Pant. Acid 9.08 mg 5 182%
Vitamin C 557.37 mg 90 619% Phosphorous 1979.6 mg 700 283%
Vitamin D 12.13 mcg 5 242% Potassium 6978.81 mg 4700 148%
Vitamin D 485 IU Riboflavin 2.99 mg 1.3 230%
Vitamin E 32.2 mg 15 215% Selenium 172.3 mcg 55 313%
Vitamin E 48.06 IU Sodium 1892.64 mg 1500 126%
Calcium 833.02 mg 1000 83% Thiamin 3.95 mg 1.2 329%
Cholesterol 729.15 mg Water 1952.49 g
Copper 2.3 mg 0.9 255% Zinc 15.48 mg 11 141%
Iron 18.63 mg 8 233%

Note: in the above table calcium is lower, but this is of no concern since higher calcium levels are only required because salt strips it from our bones. My salt intake is non-existent and so my calcium intake is optimal. 

So today I have lost a total of 20 pounds, and all in just under a month. It really hasn’t taken much effort. My general well-being has improved so much I can barely believe it – I feel so energetic and healthy, happy and refreshed. I know that it is my nutrient intake, and exercise regime that are playing a key role in this elevated mood because on the occasional day I don’t exercise, or I don’t hit my nutrient target, my mood suffers and I become lethargic. I never realised that the most important factor for weight loss was doing things in life that create this sense of wellness. When you feel so good the tough  life hurdles that were so intimidating previously just seem to melt away. I honestly have never felt this good in all of my life, all depression has left me, and the weight dropping off is more a bonus than a focus, because I feel I am alive….for the first time!

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